Domperidone structure

Chemical Structure of Domperidone

Domperidone (Motilium) is an antiemetic medication used to treat nausea, vomiting and delayed stomach emptying. Strangely, it can also be used to increase the breast milk supply in women who are having trouble breastfeeding as it increases the level of prolactin in the blood.

The normal dose is one tablet, three or four times a day, 30 minutes before meals.

It may be used with caution if pregnant or breastfeeding, and patients with breast cancer, liver and kidney disease. Do not take it if suffering from some forms of pituitary gland tumour.

The side effects are minimal, but uncommonly a dry mouth and stomach cramps may occur. Domperidone may interact with antacids, anticholinergics, imidazole antifungals, macrolide antibiotics and nefazodone.

It is a remarkably safe and effective medication introduced in the mid-1980s that is marvellous for motion sickness. It does not cause dependence or addiction, but is designed for short-term use.

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