Chemical Structure of Toremifene (C26H28ClNO)

Toremifene (Fareston) is an antineoplastic medication. It has been used since 1998 as a tablet to treat some types of breast cancer in post-menopausal women.

It is not to be used in breastfeeding, children or pregnancy unless essential for the health of the mother.

Use toremifene with caution in patients with angina, heart disease, diabetes, liver disease or history of recent blood clots.

Do not take it if the cancer of breast is oestrogen receptor negative, if suffering severe liver disease or any condition affecting the lining of the uterus.

Common side effects include excess calcium in the blood, hot flushes, sweating, dizziness, diarrhoea, nausea and vaginal discharge.

Less common side effects include vomiting, unusual bleeding from the vagina, swelling of tissue, muscle pain and blood clots.

Toremifene may interact with phenytoin, carbamazepine, phenobarbitone, thiazide diuretics, warfarin, ketoconazole and macrolide antibiotics.

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