Chemical structure of Trilostane

Trilostane is an unusual medication that is used to treat two very different conditions – breast cancer and excess activity of the adrenal gland (hyperaldosteronism or Conn syndrome).

It must not to be used in pregnancy, breastfeeding, children or if suffering from severe kidney or liver disease. Use trilostane with caution with physical stress, or any kidney or liver disease.  Non-hormonal contraception must be used by women.

Side effects may include flushing, nausea, a runny nose and diarrhoea. Interactions are possible with potassium, amiloride, triamterene and high potassium foods (eg. bananas, apricots).

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